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Sodium azide is the reagent of choice to prepare sterically hindered amines, triazoles and tetrazoles, functional moieties often encountered in new APIs (Active Pharmaceutical Ingredients). However, the use of azides in batch-wise productions is severely hampered by safety risks. Sodium azide is highly toxic, can...

Telzerow, Aline; Paris, Juraj; Hakansson, Maria; Gonzalez-Sabin, Javier; Rios-Lombardia, Nicolas; Schuermann, Martin; Groeger, Harald; Moris, Francisco; Kourist, Robert; Schwab, Helmut; et al. Amine transaminase from Exophiala xenobiotica - Crystal structure and engineering of a fold IV transaminase that naturally converts biaryl ketones. ACS Catalysis (2019), 9 (2),...

Engleder, Matthias; Strohmeier, Gernot A.; Weber, Hansjoerg; Steinkellner, Georg; Leitner, Erich; Mueller, Monika; Mink, Daniel; Schuermann, Martin; Gruber, Karl; Pichler, Harald Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives. Angewandte Chemie, International Edition (2019), 58 (22), 7480-7484....